Second-generation antidepressants

Second-generation antidepressants

In late 1970's to mid 1980's a group of structurally different antidepressant drugs were developed, they were not significantly more effective or safer than the TCAs, they did have a faster onset of effects with less side effects, examples are:

  • Maprotiline (Ludiomol): Has a long half-life, blocks NE reuptake.
  • Amoxapine (Asendin): Inhibits NE reuptake, has some Parkinson-like symptoms due to its blocking of DA receptors, overdosage may be fatal.
  • Trazodone (Desyrel): Its mechanism is unclear, as it does not block the reuptake of NE or 5-HT, however it is known to block 5-HT2 receptors. It has a short onset of action less than a week, with optimal effect in 2-5 weeks.
  • Bupropion (Wellbutrin or Zyban): Blocks DA reuptake but does not possess any reinforcing effects, used to treat ADHD in children, also believed to stop nicotine craving.


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