Supplies blood to most of the temporal lobe, anterolateral frontal lobe, and parietal lobe.

Perforating branches supply the posterior limb of the internal capsule, part of the head and body of the caudate and globus pallidus.

Blockage Affects:

Unilateral occlusion of Middle Cerebral Arteries at the stem ( proximal M1 segment ) results in:

• Contralateral hemiplegia affecting face, arm, and leg ( lesser ).
• Homonymous hemianopia - Ipsilateral head / eye deviation.
• If on left there is global aphasia.

Usually occlusion is embolic in nature.
Thrombotic occlusion more common in carotids.